2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. HCN Channel

HCN Channel

Hyperpolarization activated cyclic nucleotide gated channels

HCN Channel

Related Products

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Hyperpolarization- and Cyclic Nucleotide-gated (HCN) channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channels. The HCN family consists of four members (HCN1-4). HCN channels represent the molecular correlates of I(h), a hyperpolarization-activated current best known for its role in controlling heart rate and in the regulation of neuronal resting membrane potential and excitability.

HCN channels are unique among vertebrate voltage-gated ion channels, in that they have a reverse voltage-dependence that leads to activation upon hyperpolarization. HCN channels are encoded by four genes (HCN1-4) and are widely expressed throughout the heart and the central nervous system.

HCN Channel Related Products (21):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-101346
    ZD7288
    		Inhibitor 99.94%
    ZD7288 (ICI D7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker.
    ZD7288
  • HY-B0162A
    Ivabradine hydrochloride
    		Inhibitor 99.71%
    Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If). Ivabradine hydrochloride reduces dose-dependently heart rate without modification of blood pressure. Ivabradine hydrochloride shows anticonvulsant, anti-ischaemic and anti-anginal activity.
    Ivabradine hydrochloride
  • HY-13422
    Zatebradine hydrochloride
    		Antagonist 99.06%
    Zatebradine (UL-FS-49 (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 µM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively.
    Zatebradine hydrochloride
  • HY-13422A
    Zatebradine
    		Antagonist 99.27%
    Zatebradine (UL-FS-49 (free base); UL-FS-49CL (free base)) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 value of 1.96 µM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM and 1.88 µM, respectively.
    Zatebradine
  • HY-18940A
    Cilobradine hydrochloride
    		Inhibitor 99.73%
    Cilobradine hydrochloride is a HCN channel blocker.
    Cilobradine hydrochloride
  • HY-160505
    RO-275
    		Inhibitor ≥99.0%
    RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.
    RO-275
  • HY-119102
    BPU-11
    		98.01%
    BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand.
    BPU-11
  • HY-137016A
    8-Pcpt-cGMP sodium
    		Agonist ≥99.0%
    8-Pcpt-cGMP sodium is the sodium salt form of 8-Pcpt-cGMP (HY-137016).
    8-Pcpt-cGMP sodium
  • HY-B0162
    Ivabradine
    		Inhibitor
    Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If).
    Ivabradine
  • HY-U00309
    YM758
    		Inhibitor 99.71%
    YM758 is a “funny” If current channel (If channel) inhibitor.
    YM758
  • HY-161092
    KIO-301 chloride
    		Inhibitor
    KIO-301 chloride is an azobenzene photoswitch compound that can block voltage-gated ion channels, including hyperpolarisation-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium channels during exposure to visible light.
    KIO-301 chloride
  • HY-135110
    Rp-8-Br-cGMPS sodium
    		Activator
    Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca2+-ATPase activator.
    Rp-8-Br-cGMPS sodium
  • HY-B0162S
    Ivabradine-d6
    Ivabradine-d<sub>6</sub>
  • HY-160209
    KIO-301
    		Inhibitor
    KIO-301
  • HY-163455
    pan-HCN-IN-1
    		Inhibitor
    pan-HCN-IN-1 (Compound J&J12e) is an inhibitor for hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channel, with IC50 of 58 nM.
    pan-HCN-IN-1
  • HY-161092A
    KIO-301 chloride (hydrochloride)
    		Inhibitor 99.61%
    KIO-301 chloride (hydrochloride)
  • HY-B0162AR
    Ivabradine (hydrochloride) (Standard)
    		Inhibitor
    Ivabradine (hydrochloride) (Standard)
  • HY-137639
    Sp-8-Br-cGMPS
    		Agonist
    Sp-8-Br-cGMPS is an analog of cGMP.
    Sp-8-Br-cGMPS
  • HY-137016
    8-Pcpt-cGMP
    		Agonist
    8-Pcpt-cGMP is an agonist for cyclic nucleotide-gated (CNG) channel with an EC50 of 0.
    8-Pcpt-cGMP
  • HY-135110A
    Rp-8-Br-cGMPS
    		Activator
    Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca2+-ATPase activator.
    Rp-8-Br-cGMPS